Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks Short title: Profile of prognostic DNA methylation in AML
نویسندگان
چکیده
Institutions: Department of Internal Medicine / Hematology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden; Institut National de la Santé et de la Recherche Médicale, Unité 892, Angers, France; Service des Maladies du Sang, Centre Hospitalier Universitaire, Angers, France; Institute for Biomedicine and Nutrition, NOVUM, Karolinska Institutet, Stockholm, Sweden; Department of Internal Medicine III, University Hospital, Ulm, Germany ; Laboratoire d Hematologie, Centre Hospitalier Universitaire, Angers, France ; Department of Hematology, Örebro University Hospital, Örebro, Sweden; Department of Hematology, Uppsala University Hospital, Uppsala, Sweden
منابع مشابه
Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks.
Cytogenetically normal acute myeloid leukemia (CN-AML) compose between 40% and 50% of all adult acute myeloid leukemia (AML) cases. In this clinically diverse group, molecular aberrations, such as FLT3-ITD, NPM1, and CEBPA mutations, recently have added to the prognostic accuracy. Aberrant DNA methylation is a hallmark of cancer, including AML. We investigated in total 118 CN-AML samples in a t...
متن کاملMYELOID NEOPLASIA Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks
1Department of Internal Medicine/Hematology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden; 2Inserm, Unité 892, Angers, France; 3Service des Maladies du Sang, Centre Hospitalier Universitaire, Angers, France; 4Institute for Biomedicine and Nutrition, NOVUM, Karolinska Institutet, Stockholm, Sweden; 5Department of Internal Medicine III, University Hospital, Ul...
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Aberrant DNA methylation has been reported as an important phenotype in acute myeloid leukemia. However the clinical significance of methylation changes has not been clear yet. In this study methylation Specific Melting Curve Analysis (MS-MCA) and real time PCR was used to assess the CDKN2B promoter hyper-methylation and gene expression in 59 Iranian acute myeloid leukemia (AML) patients. The i...
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Aberrant DNA methylation has been reported as an important phenotype in acute myeloid leukemia. However the clinical significance of methylation changes has not been clear yet. In this study methylation Specific Melting Curve Analysis (MS-MCA) and real time PCR was used to assess the CDKN2B promoter hyper-methylation and gene expression in 59 Iranian acute myeloid leukemia (AML) patients. The i...
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Background: Acute myeloid leukemia (AML) is a malignant disorder involving blood cells, characterized by obstructed or distorted differentiation of hematopoietic stem cells. In cytogenetically normal AML (CN AML), molecular abnormalities in NPM, FLT3, CEBPA, and BAALC genes are observed. Initially, high BAALC (Brain and Acute Leukemia Cytoplasmic gene) expression was introduced in a study on AM...
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